By Richard J. Glassock (auth.), Claudio Ponticelli, Luigi Minetti, Giuseppo D’Amico (eds.)
RICHARD J. GLASSOCK Introducing a systematic symposium is an doubtful and hard job. The comments must never be too particular lest the participant's later contributions be intruded upon, but an summary of the ambitions and pursuits of the convention will be provided in an inquisitive and stimulating type. maybe a compromise place will be to make a number of common statements and pose a restricted variety of questions which optimistically could then be addressed dur ing the formal or casual parts of the assembly. A end incorpo of the relevance of the categorical subject to the extra ranking a few views international problems with affliction and its results may be applicable. The pursuits and targets of this convention, as set forth via its organizers, Professors Ponti celli, D'Amico and Minetti, are quite easy and directly ahead; specifically, to study and elucidate the immunopathophysiology of cryoimmunoglobulins and auto-antibodies to immunoglobulins (lg) and, secondarily, to discover the potential participation of those disordered states in glomerular damage. As such, this convention is especially dedicated to an research of 2 houses of yes species of the globulin fraction of serum proteins, particularly the facility to self affiliate at the foundation of immune interactions and to shape insoluble aggregates while uncovered to decreased ambient temperature. As we will see, those houses are frequently dis tinctly related.
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Additional resources for Antiglobulins, cryoglobulins and glomerulonephritis: Second International Milano Meeting of Nephrology 30 September – 1 October 1985
Monoclonal antibodies Grass levan [32-6 fructosan Binding to Bacterial levan [32-1, 2-6 fructosan A48 IPCIO MOPC173 X24 J606 + + + + 2-1-3 2-8-2 2-11-1 2-12-10 2-28-9 3-76-4 3-14-9 3-27-6 3-9-9 3-101-14 + ± + + + + + Inulin [32-1 fructosan + + + + + + + + + + + Galactan [31-6 fructosan + + 33 UPCIOId in the nati-Ievan response. These are idiotypes which otherwise represent a minor component of a conventional immune response elicited by immunization with bacterial levan. In this study it was shown that A48 or UPCIOId-specific helper T cells were probably responsible for A48UPCIOId dominance.
Agnello V, Arbetter A, de Kasep GI, Powell R, Tan EM, Joslin F: Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-reactive idiotype. J Exp Med 151: 1514, 1980. 37. Bona CA, Finley S, Waters S, Kunkel HG: Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments. J Exp Med 156: 986-999, 1982. 38.
This means that epibodies recognize the same aminoacid sequence on CDR-I of light chain and on Fc-gamma, the antigen of the RF. I was very happy that dr GeItner found the same phenomenon in spontaneous and polyclonal RF. Initially I thought that epibody was restricted to anti-Id antibodies specific for RF but now it seems, that actually epibodies are seen in other systems, particularly in myastenia gravis. AGNELLO: I have a question for dr Bona: in the human RF there doesn't appear to be VH restriction, whereas in the mouse it appears to be highly restricted.