By Institute of Medicine, Board on Population Health and Public Health Practice, Committee on the Review of the Scientific Literature on Amyotrophic Lateral Sclerosis in Veterans

Amyotrophic lateral sclerosis (ALS) our Lou Gehrig's illness is a deadly, usually non-familial affliction that has effects on the fearful approach of people through inflicting the degeneration of nerve cells within the mind and spinal twine. The degeneration halts communique among the frightened procedure and voluntary muscle groups within the physique. This results in muscle paralysis and at last the muscle groups that relief in respiring are have an effect on; inflicting breathing to fail. The affliction, which impacts 20,000-30,000 women and men within the usa at any given time, has no powerful therapy; most folks with ALS die from respiration failure inside five years of the onset of symptoms.

Recent epidemiologic experiences document an organization among the advance of ALS and past provider within the U.S. army. The stories evaluated both veterans of the 1991 Persian Gulf conflict or veterans who served within the army within the interval 1910-1982. because of those findings, the dept of Veterans Affairs (VA) requested the nationwide Academies to behavior an evaluation of the aptitude courting among army provider and the later improvement of ALS. The undertaking was once assigned to the Institute of medication (IOM), which appointed a committee and gave it the duty of comparing the clinical literature on ALS in veterans.

The committee begun its paintings by way of opting for scientific and medical literature on ALS. PubMed, a database created and controlled through the nationwide Library of drugs. Amyotrophic Lateral Sclerosis in Veterans; evaluate of the medical Literature provides the findings of this committee. The committee reviewed, evaluated, and summarized the medical literature on ALS in veterans, composed basically of peer-reviewed, released literature. This document contains the suggestions of the committee.

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Extra info for Amyotrophic Lateral Sclerosis in Veterans: Review of the Scientific Literature

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Merritt's Neurology. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins. Pp. 708714. Siddique N, Sufit R, Siddique T. 1999. Degenerative motor, sensory, and autonomic disorders. In: Goetz CG, Pappert EJ, Editors. Textbook of Clinical Neurology. 1st ed. B. Saunders Company. Pp. 695-717. Veldink JH, Kalmijn S, Groeneveld GJ, Titulaer MJ, Wokke JH, van den Berg LH. 2005. Physical activity and the association with sporadic ALS. Neurology 64(2):241-245. 1 illustrates three possible conceptual models linking military service or other risk factors that might be related to military service with amyotrophic lateral sclerosis (ALS).

The authors suggest a link between a specific myocoplasmal infection and ALS; however, comparison subjects were not adequately described to support a judgment of the quality of the study. In addition, the ALS subjects were atypical in their clinical presentation. For these reasons, the data presented do not clearly support a relationship between mycoplasmal infection in Gulf War veterans and ALS. LEAD In a case-control study conducted in New England, 109 newly diagnosed ALS patients from two centers (the Neuromuscular Research Unit at New England Medical Center and the Neurophysiology Laboratory at Brigham and Women’s Hospital) and population controls were interviewed about lead exposure (Kamel et al.

Brain 128(Pt 3):472-476. Cox PA, Sacks OW. 2002. Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology 58(6):956-959. Cox PA, Banack SA, Murch SJ. 2003. Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proceedings of the National Academy of Sciences of the United States of America 100(23):13380-13383. Cox PA, Banack SA, Murch SJ, Rasmussen U, Tien G, Bidigare RR, Metcalf JS, Morrison LF, Codd GA, Bergman B.

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