By Erika Armstrong

“Ladies and gents, welcome aboard your flight. As you step onto my plane, take a brief look into the cockpit. Yep, that’s me sitting within the captains’ seat, and that’s my first officer giggling approximately how he by accident locked himself out of his lodge room. bare. Again.

We’re either a bit ripe from flying for the final 5 days, yet we’re nonetheless smiling simply because now we have spent years and millions of hours education and dwelling an unusual way of life to be up right here for you.

For the following couple of hours, you might want to flip your existence over to us. It’s difficult to belief others, and there are moments for those who don’t have a call approximately being on top of things. in the course of these moments, you’ll simply need to tighten your seatbelt and belief that others gets you thru the storm.

Our direction this present day will take you thru a section of my existence up within the air, and you'll see stuff you may perhaps by no means think. considering i've been locked within the cockpit with males for numerous hundreds of thousands of hours through the years, i've been given a standpoint few get to event. that will help you see a distinct viewpoint, too, i'm supplying you with a list to take advantage of as we movement alongside our direction. it is going to take you from gate to gate, and while we’re performed, we'll have either discovered a bit extra approximately what it takes to fly.

Now…just chill out and sit back. It’s going to be a bumpy ride.”

Erika Armstrong has labored each point of aviation in her twenty-five years within the undefined, together with a world company airline captain. She is an award-winning employees author for Colorado Serenity journal and is a certified pilot columnist for Disciples of Flight, NYC Aviation, Contrails, Flying, LinkedIn, and enterprise Insider and is the landlord of innovative Aviation Consulting.

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Studies 21 · Project Title: BILE METABOLISM ACID SIGNALING AND HEPATIC CHOLESTOROL Principal Investigator & Institution: Dent, Paul; Associate Professor; Virginia Commonwealth University Richmond, VA 232980568 Timing: Fiscal Year 2002; Project Start 01-JUL-2002; Project End 30-JUN-2007 Summary: (provided by applicant): Bile acids may help to coordinately regulate cholesterol and phospholipid metabolism in the hepatocyte by modulating the expression of genes encoding bile acid biosynthetic enzymes and phospholipid transport proteins.

These studies will make a significant contribution to the understanding of the only routes by which significant cholesterol is removed from the body. In this respect the applicant anticipates that the results will impact upon the treatment of cardiovascular diseases well as having significance for fundamental biological questions of the control of cholesterol homeostasis. ; Pediatrics; University of Arizona P O Box 3308 Tucson, AZ 857223308 Timing: Fiscal Year 2001; Project Start 15-MAR-1999; Project End 29-FEB-2004 Summary: Plasma membrane caveolae are specialized domains that have a central role in modulating intracellular cholesterol homeostasis.

Aim 2: To determine changes in cholesterol efflux and resulting changes in cellular cholesterol/cholesterol esters by over-expression of human macrophage CEH cDNA and to examine the regulation of CEH by HDL-mediated signaling. Aim 3: To determine the mechanisms whereby intracellular cholesterol/oxysterols levels regulate CEH expression. Aim 4: To obtain in vivo "proof of concept" by introducing human macrophage CEH transgene in LDL-receptor knockout (LDLR-/-) mice and attenuating cholesterol-feeding induced atherosclerosis.

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